NONO (Homo sapiens)
RRM

RBP Information

Pfam ID Interpro ID Gene ID CISBP-RNA ID Sequence source
PF00076 (RRMs_3D) IPR000504 ENSG00000147140 T080486_2.00 Ensembl (2018-Dec-8)

Directly determined binding motifs

Name/Motif ID Species Sequence Logo IUPAC Type/Study/Study ID JPLE
e-dist
NONO
M00505_2.00		 Homo sapiens AGGGA SELEX
Cook et al.(2011)
488_9001221 		(Direct)
NONO
M00507_2.00		 Homo sapiens Sequence logo not available GAGAGGAAC SELEX
Cook et al.(2011)
490_12403470 		(Direct)
NONO
M13047_2.00		 Homo sapiens NGURGUKK JPLE
Sasse et al.(2025)
RM_Hom.sap_ENSG00000147140 		0.055

Motifs from related RBPs

Name/Motif ID Species Sequence Logo IUPAC Type/Study/Study ID RBD
Identity
SFPQ
M00809_2.00 		Homo sapiens UAGUG RNA-Bind-n-Seq
Dominguez et al.(2018)
0.730
SFPQ
M00808_2.00 		Homo sapiens WGUAAN RNA-Bind-n-Seq
Dominguez et al.(2018)
0.730
SFPQ
M00506_2.00 		Homo sapiens Sequence logo not available UGGAGAGGAAC SELEX
Cook et al.(2011)
0.730
SFPQ
M00190_2.00 		Homo sapiens KURRUKK RNAcompete
Ray et al.(2013)
0.730
For this family, RBPs with RBD identity > 0.7 will likely have a similar motif

Motifs from training set RBPs that strongly contributed to the reconstructed motif

Name/Motif ID Species Sequence Logo IUPAC Type/Study/Study ID e-dist (%
contribution)
SFPQ
M00190_2.00 		Homo sapiens KURRUKK RNAcompete
Ray et al.(2013)
RNCMPT00177 		0.055
(90.91%)

RNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000276079 RRM 71 147
ENSP00000276079 RRM 145 213
ENSP00000362947 RRM 71 147
ENSP00000362947 RRM 145 213
ENSP00000362963 RRM 71 147
ENSP00000362963 RRM 145 213
ENSP00000406673 RRM 71 148
ENSP00000406673 RRM 145 207
ENSP00000409773 RRM 1 41
ENSP00000409773 RRM 35 75
ENSP00000410299 RRM 71 121
ENSP00000413350 RRM 71 148
ENSP00000441364 RRM 71 147
ENSP00000441364 RRM 145 213

RNA contacting residues

Links

Other RRM family RBPs
Other Homo sapiens RBPs

123 Related RBPs

Due to potential differences in protein isoforms or tested constructs, some RBPs without inferred motifs might appear in this list.
Name Species Gene ID Motif Evidence RBD
Identity		 Action
NONO Gorilla gorilla ENSGGOG00000006194 I 1.000
NONO Loxodonta africana ENSLAFG00000013422 I 1.000
NONO Microcebus murinus ENSMICG00000000232 I 1.000
NONO Myotis lucifugus ENSMLUG00000002489 I 1.000
NONO Macaca mulatta ENSMMUG00000020481 I 1.000
ENSMPUG00000004937 Mustela putorius furo ENSMPUG00000004937 I 1.000
Nono Mus musculus ENSMUSG00000031311 I 1.000
ENSNLEG00000001278 Nomascus leucogenys ENSNLEG00000001278 I 1.000
ENSOCUG00000021848 Oryctolagus cuniculus ENSOCUG00000021848 I 1.000
NONO Otolemur garnettii ENSOGAG00000004834 I 1.000
ENSPANG00000013979 Papio anubis ENSPANG00000013979 I 1.000
NONO Procavia capensis ENSPCAG00000002541 I 1.000
ENSPPYG00000020451 Pongo abelii ENSPPYG00000020451 I 1.000
NONO Pan troglodytes ENSPTRG00000022010 I 1.000
NONO Pteropus vampyrus ENSPVAG00000016503 I 1.000
Nono Rattus norvegicus ENSRNOG00000003689 I 1.000
NONO Sus scrofa ENSSSCG00000023245 I 1.000
ENSSTOG00000015869 Ictidomys tridecemlineatus ENSSTOG00000015869 I 1.000
NONO Tursiops truncatus ENSTTRG00000009605 I 1.000
NONO Vicugna pacos ENSVPAG00000002272 I 1.000
ENSBTAP00000016122-D1 Bos grunniens ENSBTAP00000016122-D1 I 1.000
ENSP00000276079 Macaca fascicularis ENSP00000276079 I 1.000
Myotis_brandtii_NONO_10007307 Myotis brandtii Myotis_brandtii_NONO_10007307 I 1.000
ENSAMEG00000016057 Ailuropoda melanoleuca ENSAMEG00000016057 I 1.000
NONO Bos taurus ENSBTAG00000012152 I 1.000
ENSCAFG00000003207 Canis familiaris ENSCAFG00000003207 I 1.000
ENSCAFG00000017071 Canis familiaris ENSCAFG00000017071 I 1.000
ENSCJAG00000036744 Callithrix jacchus ENSCJAG00000036744 I 1.000
ENSCPOG00000010263 Cavia porcellus ENSCPOG00000010263 I 1.000
NONO Equus caballus ENSECAG00000008502 I 1.000
NONO Erinaceus europaeus ENSEEUG00000014404 I 1.000
NONO Felis catus ENSFCAG00000014807 I 1.000
ENSMEUG00000004294 Macropus eugenii ENSMEUG00000004294 I 0.993
NONO Monodelphis domestica ENSMODG00000004445 I 0.993
ENSOARG00000016966 Ovis aries ENSOARG00000016966 I 0.993
NONO Sorex araneus ENSSARG00000007959 I 0.993
ENSSHAG00000010195 Sarcophilus harrisii ENSSHAG00000010195 I 0.993
ENSCSAG00000011368 Chlorocebus sabaeus ENSCSAG00000011368 N 0.987
ENSDNOG00000003267 Dasypus novemcinctus ENSDNOG00000003267 I 0.986
ENSPSIG00000010678 Pelodiscus sinensis ENSPSIG00000010678 I 0.980
Cmyd_10013139 Chelonia mydas Cmyd_10013139 I 0.980
Ogr12033 Ophisaurus gracilis Ogr12033 I 0.980
Pvit_05344 Pogona vitticeps Pvit_05344 I 0.980
ENSCPOG00000023605 Cavia porcellus ENSCPOG00000023605 I 0.979
NONO Gallus gallus ENSGALG00000005507 I 0.973
NONO Meleagris gallopavo ENSMGAG00000008869 I 0.973
NONO Taeniopygia guttata ENSTGUG00000007048 I 0.973
Afo_R007329 Aptenodytes forsteri Afo_R007329 I 0.973
Alligator_sinensis_CCG000628.3 Alligator sinensis Alligator_sinensis_CCG000628.3 I 0.973
Brh_R000687 Buceros rhinoceros Brh_R000687 I 0.973
Tal_R004102 Tyto alba Tal_R004102 I 0.973
ENSAPLG00000002642 Anas platyrhynchos ENSAPLG00000002642 I 0.973
ENSFALG00000011765 Ficedula albicollis ENSFALG00000011765 I 0.973
NONO Anolis carolinensis ENSACAG00000015026 I 0.952
ENSCJAG00000003136 Callithrix jacchus ENSCJAG00000003136 I 0.944
Gfo_R003471 Geospiza fortis Gfo_R003471 I 0.938
Aan_R015248 Calypte anna Aan_R015248 I 0.912
ENSCAFG00000013766 Canis familiaris ENSCAFG00000013766 I 0.855
nono Xenopus tropicalis XB-GENE-1002494 I 0.839
nono.L Xenopus laevis XB-GENE-1002501 I 0.831
ENSLACG00000000598 Latimeria chalumnae ENSLACG00000000598 I 0.824
ENSCPOG00000026604 Cavia porcellus ENSCPOG00000026604 I 0.758
ENSCAFG00000030809 Canis familiaris ENSCAFG00000030809 I 0.750
ENSLACG00000014728 Latimeria chalumnae ENSLACG00000014728 I 0.747
ENSLOCG00000014739 Lepisosteus oculatus ENSLOCG00000014739 I 0.743
sfpq Xenopus tropicalis XB-GENE-5968416 I 0.743
ENSMLUG00000027090 Myotis lucifugus ENSMLUG00000027090 I 0.736
Myotis_brandtii_SFPQ_10028873 Myotis brandtii Myotis_brandtii_SFPQ_10028873 I 0.736
SFPQ Gorilla gorilla ENSGGOG00000026354 I 0.730
SFPQ Loxodonta africana ENSLAFG00000015951 I 0.730
ENSMICG00000011755 Microcebus murinus ENSMICG00000011755 I 0.730
Sfpq Mus musculus ENSMUSG00000028820 I 0.730
ENSNLEG00000010868 Nomascus leucogenys ENSNLEG00000010868 I 0.730
ENSOARG00000019439 Ovis aries ENSOARG00000019439 I 0.730
SFPQ Oryctolagus cuniculus ENSOCUG00000001877 I 0.730
SFPQ Otolemur garnettii ENSOGAG00000027710 I 0.730
SFPQ Ochotona princeps ENSOPRG00000013696 I 0.730
ENSPANG00000005380 Papio anubis ENSPANG00000005380 I 0.730
SFPQ Procavia capensis ENSPCAG00000006164 I 0.730
ENSPPYG00000001560 Pongo abelii ENSPPYG00000001560 I 0.730
ENSPSIG00000011494 Pelodiscus sinensis ENSPSIG00000011494 I 0.730
SFPQ Pan troglodytes ENSPTRG00000000518 I 0.730
Sfpq Rattus norvegicus ENSRNOG00000058461 I 0.730
ENSSTOG00000014004 Ictidomys tridecemlineatus ENSSTOG00000014004 I 0.730
sfpq Takifugu rubripes ENSTRUG00000003783 I 0.730
SFPQ Tursiops truncatus ENSTTRG00000013930 I 0.730
SFPQ Vicugna pacos ENSVPAG00000006960 I 0.730
Cmyd_10015354 Chelonia mydas Cmyd_10015354 I 0.730
ENSP00000349748-D1 Bos grunniens ENSP00000349748-D1 I 0.730
Pvit_19348 Pogona vitticeps Pvit_19348 I 0.730
ENSAMEG00000000815 Ailuropoda melanoleuca ENSAMEG00000000815 I 0.730
SFPQ Bos taurus ENSBTAG00000016328 I 0.730
ENSCAFG00000003595 Canis familiaris ENSCAFG00000003595 I 0.730
ENSCJAG00000001431 Callithrix jacchus ENSCJAG00000001431 I 0.730
ENSCPOG00000015018 Cavia porcellus ENSCPOG00000015018 I 0.730
ENSCSAG00000001082 Chlorocebus sabaeus ENSCSAG00000001082 I 0.730
SFPQ Dasypus novemcinctus ENSDNOG00000049454 I 0.730
ENSECAG00000000642 Equus caballus ENSECAG00000000642 I 0.730
SFPQ Echinops telfairi ENSETEG00000001095 I 0.730
ENSFCAG00000031287 Felis catus ENSFCAG00000031287 I 0.730
SFPQ Homo sapiens ENSG00000116560 D 0.730
ENSLOCG00000001067 Lepisosteus oculatus ENSLOCG00000001067 I 0.723
ENSMEUG00000014082 Macropus eugenii ENSMEUG00000014082 I 0.723
SFPQ Monodelphis domestica ENSMODG00000017937 I 0.723
ENSSHAG00000016107 Sarcophilus harrisii ENSSHAG00000016107 I 0.723
ENSTGUG00000001722 Taeniopygia guttata ENSTGUG00000001722 I 0.723
Aan_R015520 Calypte anna Aan_R015520 I 0.723
Afo_R013931 Aptenodytes forsteri Afo_R013931 I 0.723
Brh_R010044 Buceros rhinoceros Brh_R010044 I 0.723
Gfo_R008467 Geospiza fortis Gfo_R008467 I 0.723
Tal_R009770 Tyto alba Tal_R009770 I 0.723
ENSAPLG00000003643 Anas platyrhynchos ENSAPLG00000003643 I 0.723
nono Danio rerio ENSDARG00000020482 I 0.717
SFPQ Gallus gallus ENSGALG00000002514 I 0.716
Alligator_sinensis_CCG014919.3 Alligator sinensis Alligator_sinensis_CCG014919.3 I 0.716
pspc1 Xenopus tropicalis XB-GENE-492866 I 0.716
Sfpq Dipodomys ordii ENSDORG00000008109 I 0.709
ENSLOCG00000010832 Lepisosteus oculatus ENSLOCG00000010832 I 0.703
SFPQ Tupaia belangeri ENSTBEG00000006238 I 0.703
SFPQ Anolis carolinensis ENSACAG00000013307 I 0.703
ENSAMXG00000011538 Astyanax mexicanus ENSAMXG00000011538 I 0.703
ENSCAFG00000018271 Canis familiaris ENSCAFG00000018271 I 0.703