SFPQ (Homo sapiens)
RRM

RBP Information

Pfam ID Interpro ID Gene ID CISBP-RNA ID Sequence source
PF00076 (RRMs_3D) IPR000504 ENSG00000116560 T080439_2.00 Ensembl (2018-Dec-8)

Directly determined binding motifs

Name/Motif ID Species Sequence Logo IUPAC Type/Study/Study ID JPLE
e-dist
SFPQ
M00190_2.00		 Homo sapiens KURRUKK RNAcompete
Ray et al.(2013)
RNCMPT00177 		(Direct)
SFPQ
M00506_2.00		 Homo sapiens Sequence logo not available UGGAGAGGAAC SELEX
Cook et al.(2011)
489_12403470 		(Direct)
SFPQ
M00808_2.00		 Homo sapiens WGUAAN RNA-Bind-n-Seq
Dominguez et al.(2018)
SFPQ_5mer_logo0 		(Direct)
SFPQ
M00809_2.00		 Homo sapiens UAGUG RNA-Bind-n-Seq
Dominguez et al.(2018)
SFPQ_5mer_logo1 		(Direct)
SFPQ
M13014_2.00		 Homo sapiens NGURGKKU JPLE
Sasse et al.(2025)
RM_Hom.sap_ENSG00000116560 		0.008

Motifs from related RBPs

Name/Motif ID Species Sequence Logo IUPAC Type/Study/Study ID RBD
Identity
NONO
M00507_2.00 		Homo sapiens Sequence logo not available GAGAGGAAC SELEX
Cook et al.(2011)
0.730
NONO
M00505_2.00 		Homo sapiens AGGGA SELEX
Cook et al.(2011)
0.730
For this family, RBPs with RBD identity > 0.7 will likely have a similar motif

Motifs from training set RBPs that strongly contributed to the reconstructed motif

Name/Motif ID Species Sequence Logo IUPAC Type/Study/Study ID e-dist (%
contribution)
SFPQ
M00190_2.00 		Homo sapiens KURRUKK RNAcompete
Ray et al.(2013)
RNCMPT00177 		0.008
(88.41%)

Experimental Constructs

Motif ID Domain From To Sequence
M00190_2.00 RRM 29 106
M00190_2.00 RRM 103 171

RNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000349748 RRM 294 371
ENSP00000349748 RRM 368 436

RNA contacting residues

Links

Other RRM family RBPs
Other Homo sapiens RBPs

186 Related RBPs

Due to potential differences in protein isoforms or tested constructs, some RBPs without inferred motifs might appear in this list.
Name Species Gene ID Motif Evidence RBD
Identity		 Action
SFPQ Gorilla gorilla ENSGGOG00000026354 I 1.000
SFPQ Loxodonta africana ENSLAFG00000015951 I 1.000
ENSMICG00000011755 Microcebus murinus ENSMICG00000011755 I 1.000
Sfpq Mus musculus ENSMUSG00000028820 I 1.000
ENSNLEG00000010868 Nomascus leucogenys ENSNLEG00000010868 I 1.000
ENSOARG00000019439 Ovis aries ENSOARG00000019439 I 1.000
SFPQ Oryctolagus cuniculus ENSOCUG00000001877 I 1.000
SFPQ Otolemur garnettii ENSOGAG00000027710 I 1.000
SFPQ Ochotona princeps ENSOPRG00000013696 I 1.000
ENSPANG00000005380 Papio anubis ENSPANG00000005380 I 1.000
SFPQ Procavia capensis ENSPCAG00000006164 I 1.000
ENSPPYG00000001560 Pongo abelii ENSPPYG00000001560 I 1.000
SFPQ Pan troglodytes ENSPTRG00000000518 I 1.000
Sfpq Rattus norvegicus ENSRNOG00000058461 I 1.000
ENSSTOG00000014004 Ictidomys tridecemlineatus ENSSTOG00000014004 I 1.000
SFPQ Tursiops truncatus ENSTTRG00000013930 I 1.000
SFPQ Vicugna pacos ENSVPAG00000006960 I 1.000
ENSP00000349748-D1 Bos grunniens ENSP00000349748-D1 I 1.000
ENSAMEG00000000815 Ailuropoda melanoleuca ENSAMEG00000000815 I 1.000
SFPQ Bos taurus ENSBTAG00000016328 I 1.000
ENSCAFG00000003595 Canis familiaris ENSCAFG00000003595 I 1.000
ENSCJAG00000001431 Callithrix jacchus ENSCJAG00000001431 I 1.000
ENSCPOG00000015018 Cavia porcellus ENSCPOG00000015018 I 1.000
ENSCSAG00000001082 Chlorocebus sabaeus ENSCSAG00000001082 I 1.000
SFPQ Dasypus novemcinctus ENSDNOG00000049454 I 1.000
ENSECAG00000000642 Equus caballus ENSECAG00000000642 I 1.000
SFPQ Echinops telfairi ENSETEG00000001095 I 1.000
ENSFCAG00000031287 Felis catus ENSFCAG00000031287 I 1.000
Myotis_brandtii_SFPQ_10028873 Myotis brandtii Myotis_brandtii_SFPQ_10028873 I 0.993
ENSMLUG00000027090 Myotis lucifugus ENSMLUG00000027090 I 0.986
ENSMEUG00000014082 Macropus eugenii ENSMEUG00000014082 I 0.980
SFPQ Monodelphis domestica ENSMODG00000017937 I 0.980
ENSPSIG00000011494 Pelodiscus sinensis ENSPSIG00000011494 I 0.980
ENSSHAG00000016107 Sarcophilus harrisii ENSSHAG00000016107 I 0.980
Pvit_19348 Pogona vitticeps Pvit_19348 I 0.980
Alligator_sinensis_CCG014919.3 Alligator sinensis Alligator_sinensis_CCG014919.3 I 0.973
Sfpq Dipodomys ordii ENSDORG00000008109 I 0.973
ENSTGUG00000001722 Taeniopygia guttata ENSTGUG00000001722 I 0.966
Aan_R015520 Calypte anna Aan_R015520 I 0.966
Afo_R013931 Aptenodytes forsteri Afo_R013931 I 0.966
Brh_R010044 Buceros rhinoceros Brh_R010044 I 0.966
Cmyd_10015354 Chelonia mydas Cmyd_10015354 I 0.966
Gfo_R008467 Geospiza fortis Gfo_R008467 I 0.966
Tal_R009770 Tyto alba Tal_R009770 I 0.966
ENSAPLG00000003643 Anas platyrhynchos ENSAPLG00000003643 I 0.966
SFPQ Anolis carolinensis ENSACAG00000013307 I 0.959
SFPQ Gallus gallus ENSGALG00000002514 I 0.952
SFPQ Tupaia belangeri ENSTBEG00000006238 I 0.952
ENSCAFG00000018271 Canis familiaris ENSCAFG00000018271 I 0.952
SFPQ Pteropus vampyrus ENSPVAG00000001865 I 0.939
ENSTSYG00000009311 Tarsius syrichta ENSTSYG00000009311 I 0.918
sfpq Xenopus tropicalis XB-GENE-5968416 I 0.891
sfpq Takifugu rubripes ENSTRUG00000003783 I 0.884
ENSLACG00000014728 Latimeria chalumnae ENSLACG00000014728 I 0.879
ENSCAFG00000017608 Canis familiaris ENSCAFG00000017608 I 0.878
ENSLOCG00000001067 Lepisosteus oculatus ENSLOCG00000001067 I 0.871
SFPQ Macaca mulatta ENSMMUG00000019154 I 0.857
sfpq Tetraodon nigroviridis ENSTNIG00000011331 I 0.855
ENSAMXG00000011538 Astyanax mexicanus ENSAMXG00000011538 I 0.830
ENSGMOG00000011950 Gadus morhua ENSGMOG00000011950 I 0.827
sfpq Gasterosteus aculeatus ENSGACG00000002034 I 0.826
ENSXMAG00000016391 Xiphophorus maculatus ENSXMAG00000016391 I 0.811
ENSPFOG00000003127 Poecilia formosa ENSPFOG00000003127 I 0.804
ENSONIG00000017737 Oreochromis niloticus ENSONIG00000017737 I 0.804
ENSGMOG00000011957 Gadus morhua ENSGMOG00000011957 I 0.796
sfpq Oryzias latipes ENSORLG00000007459 I 0.795
PSPC1 Gallus gallus ENSGALG00000017142 I 0.776
PSPC1 Taeniopygia guttata ENSTGUG00000011295 I 0.776
Aan_R001274 Calypte anna Aan_R001274 I 0.776
Afo_R008576 Aptenodytes forsteri Afo_R008576 I 0.776
Brh_R000965 Buceros rhinoceros Brh_R000965 I 0.776
Ogr05221 Ophisaurus gracilis Ogr05221 I 0.776
Pvit_12920 Pogona vitticeps Pvit_12920 I 0.776
Tal_R009732 Tyto alba Tal_R009732 I 0.776
pspc1 Xenopus tropicalis XB-GENE-492866 I 0.776
PSPC1 Anolis carolinensis ENSACAG00000002093 I 0.776
ENSFALG00000008750 Ficedula albicollis ENSFALG00000008750 I 0.776
sfpq Danio rerio ENSDARG00000011564 I 0.775
ENSCHOG00000009131 Choloepus hoffmanni ENSCHOG00000009131 I 0.769
ENSLACG00000010762 Latimeria chalumnae ENSLACG00000010762 I 0.762
ENSMGAG00000004237 Meleagris gallopavo ENSMGAG00000004237 I 0.755
ENSOARG00000014163 Ovis aries ENSOARG00000014163 I 0.755
PSPC1 Sus scrofa ENSSSCG00000009569 I 0.755
PSPC1 Tursiops truncatus ENSTTRG00000003343 I 0.755
ENSBTAP00000005134-D1 Bos grunniens ENSBTAP00000005134-D1 I 0.755
PSPC1 Bos taurus ENSBTAG00000003934 I 0.755
Pspc1 Dipodomys ordii ENSDORG00000016050 I 0.755
PSPC1 Erinaceus europaeus ENSEEUG00000011288 I 0.755
Alligator_sinensis_CCG002824.1 Alligator sinensis Alligator_sinensis_CCG002824.1 I 0.752
PSPC1 Homo sapiens ENSG00000121390 I 0.748
PSPC1 Gorilla gorilla ENSGGOG00000003414 I 0.748
PSPC1 Loxodonta africana ENSLAFG00000010968 I 0.748
ENSMEUG00000000476 Macropus eugenii ENSMEUG00000000476 I 0.748
PSPC1 Myotis lucifugus ENSMLUG00000017663 I 0.748
PSPC1 Macaca mulatta ENSMMUG00000020262 I 0.748
PSPC1 Monodelphis domestica ENSMODG00000008029 I 0.748
ENSMPUG00000013347 Mustela putorius furo ENSMPUG00000013347 I 0.748
Pspc1 Mus musculus ENSMUSG00000021938 I 0.748
ENSNLEG00000001294 Nomascus leucogenys ENSNLEG00000001294 I 0.748
PSPC1 Oryctolagus cuniculus ENSOCUG00000006153 I 0.748
PSPC1 Otolemur garnettii ENSOGAG00000012643 I 0.748
ENSPANG00000001992 Papio anubis ENSPANG00000001992 I 0.748
ENSPPYG00000005186 Pongo abelii ENSPPYG00000005186 I 0.748
ENSPSIG00000005168 Pelodiscus sinensis ENSPSIG00000005168 I 0.748
PSPC1 Pan troglodytes ENSPTRG00000005677 I 0.748
Pspc1 Rattus norvegicus ENSRNOG00000020782 I 0.748
PSPC1 Sorex araneus ENSSARG00000000888 I 0.748
ENSSHAG00000004696 Sarcophilus harrisii ENSSHAG00000004696 I 0.748
ENSSTOG00000026833 Ictidomys tridecemlineatus ENSSTOG00000026833 I 0.748
ENSAMEG00000017420 Ailuropoda melanoleuca ENSAMEG00000017420 I 0.748
PSPC1 Choloepus hoffmanni ENSCHOG00000008913 I 0.748
PSPC1 Callithrix jacchus ENSCJAG00000004554 I 0.748
PSPC1 Cavia porcellus ENSCPOG00000000395 I 0.748
PSPC1 Dasypus novemcinctus ENSDNOG00000011078 I 0.748
PSPC1 Felis catus ENSFCAG00000027841 I 0.748
PSPC1 Pteropus vampyrus ENSPVAG00000005036 I 0.741
ENSAMXG00000015717 Astyanax mexicanus ENSAMXG00000015717 I 0.741
ENSPSIG00000010678 Pelodiscus sinensis ENSPSIG00000010678 I 0.736
Alligator_sinensis_CCG000628.3 Alligator sinensis Alligator_sinensis_CCG000628.3 I 0.736
Cmyd_10013139 Chelonia mydas Cmyd_10013139 I 0.736
ENSLACG00000000598 Latimeria chalumnae ENSLACG00000000598 I 0.735
ENSLOCG00000010832 Lepisosteus oculatus ENSLOCG00000010832 I 0.735
ENSLOCG00000014739 Lepisosteus oculatus ENSLOCG00000014739 I 0.735
NONO Homo sapiens ENSG00000147140 D 0.730
NONO Gallus gallus ENSGALG00000005507 I 0.730
NONO Gorilla gorilla ENSGGOG00000006194 I 0.730
NONO Loxodonta africana ENSLAFG00000013422 I 0.730
NONO Meleagris gallopavo ENSMGAG00000008869 I 0.730
NONO Microcebus murinus ENSMICG00000000232 I 0.730
NONO Myotis lucifugus ENSMLUG00000002489 I 0.730
NONO Macaca mulatta ENSMMUG00000020481 I 0.730
ENSMPUG00000004937 Mustela putorius furo ENSMPUG00000004937 I 0.730
Nono Mus musculus ENSMUSG00000031311 I 0.730
ENSNLEG00000001278 Nomascus leucogenys ENSNLEG00000001278 I 0.730
ENSOCUG00000021848 Oryctolagus cuniculus ENSOCUG00000021848 I 0.730
NONO Otolemur garnettii ENSOGAG00000004834 I 0.730
ENSPANG00000013979 Papio anubis ENSPANG00000013979 I 0.730
NONO Procavia capensis ENSPCAG00000002541 I 0.730
ENSPFOG00000003362 Poecilia formosa ENSPFOG00000003362 I 0.730
ENSPPYG00000020451 Pongo abelii ENSPPYG00000020451 I 0.730
NONO Pan troglodytes ENSPTRG00000022010 I 0.730
NONO Pteropus vampyrus ENSPVAG00000016503 I 0.730
Nono Rattus norvegicus ENSRNOG00000003689 I 0.730
NONO Sus scrofa ENSSSCG00000023245 I 0.730
ENSSTOG00000015869 Ictidomys tridecemlineatus ENSSTOG00000015869 I 0.730
NONO Taeniopygia guttata ENSTGUG00000007048 I 0.730
NONO Tursiops truncatus ENSTTRG00000009605 I 0.730
NONO Vicugna pacos ENSVPAG00000002272 I 0.730
Afo_R007329 Aptenodytes forsteri Afo_R007329 I 0.730
Brh_R000687 Buceros rhinoceros Brh_R000687 I 0.730
ENSBTAP00000016122-D1 Bos grunniens ENSBTAP00000016122-D1 I 0.730
ENSP00000276079 Macaca fascicularis ENSP00000276079 I 0.730
Myotis_brandtii_NONO_10007307 Myotis brandtii Myotis_brandtii_NONO_10007307 I 0.730
Ogr12033 Ophisaurus gracilis Ogr12033 I 0.730
Pvit_05344 Pogona vitticeps Pvit_05344 I 0.730
Tal_R004102 Tyto alba Tal_R004102 I 0.730
ENSAMEG00000016057 Ailuropoda melanoleuca ENSAMEG00000016057 I 0.730
ENSAPLG00000002642 Anas platyrhynchos ENSAPLG00000002642 I 0.730
NONO Bos taurus ENSBTAG00000012152 I 0.730
ENSCAFG00000003207 Canis familiaris ENSCAFG00000003207 I 0.730
ENSCAFG00000017071 Canis familiaris ENSCAFG00000017071 I 0.730
ENSCJAG00000036744 Callithrix jacchus ENSCJAG00000036744 I 0.730
ENSCPOG00000010263 Cavia porcellus ENSCPOG00000010263 I 0.730
ENSDNOG00000003267 Dasypus novemcinctus ENSDNOG00000003267 I 0.730
NONO Equus caballus ENSECAG00000008502 I 0.730
NONO Erinaceus europaeus ENSEEUG00000014404 I 0.730
ENSFALG00000011765 Ficedula albicollis ENSFALG00000011765 I 0.730
NONO Felis catus ENSFCAG00000014807 I 0.730
ENSPMAG00000005583 Petromyzon marinus ENSPMAG00000005583 I 0.728
nono.L Xenopus laevis XB-GENE-1002501 I 0.728
ENSMEUG00000004294 Macropus eugenii ENSMEUG00000004294 I 0.723
NONO Monodelphis domestica ENSMODG00000004445 I 0.723
ENSOARG00000016966 Ovis aries ENSOARG00000016966 I 0.723
NONO Sorex araneus ENSSARG00000007959 I 0.723
ENSSHAG00000010195 Sarcophilus harrisii ENSSHAG00000010195 I 0.723
nono Xenopus tropicalis XB-GENE-1002494 I 0.723
ENSCPOG00000023605 Cavia porcellus ENSCPOG00000023605 I 0.723
ENSGMOG00000015074 Gadus morhua ENSGMOG00000015074 I 0.721
ENSAMXG00000006846 Astyanax mexicanus ENSAMXG00000006846 I 0.721
ENSXMAG00000007929 Xiphophorus maculatus ENSXMAG00000007929 I 0.716
Aan_R015248 Calypte anna Aan_R015248 I 0.716
NONO Anolis carolinensis ENSACAG00000015026 I 0.716
pspc1 Danio rerio ENSDARG00000006621 I 0.714
nono Danio rerio ENSDARG00000020482 I 0.714
ENSORLG00000004232 Oryzias latipes ENSORLG00000004232 I 0.707
ENSCJAG00000003136 Callithrix jacchus ENSCJAG00000003136 I 0.703